Clinical Trials on Two Additive Solutions for the Post-thaw Preservation of Red Blood Cells Held for Three Weeks at 4 C
Abstract
An optimized additive solution was developed for the post-thaw preservation of red cells which contained adenine, glucose, disodium phosphate, and citrate buffer. This solution, called AS-17, was compared to Miles AS-3 solution in a clinical trial using 40 subjects (N=20 ea). Fresh-frozen red cells were thawed and deglycerolized after 1-18 months and subjected to a second period of storage in either AS-3 or AS-17 solution for as long as 3 weeks at refrigerator temperatures. Both solutions yielded red cells with 24-hour survivals in excess of 75%. The AS-17 solution produced improved pH, P50, and 2, 3-DPG maintenance compared with the AS-3, but both solutions appear adequate for 3 weeks of post-thaw storage.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 29, 1993
- Accession Number
- ADA266470
Entities
People
- G. L. Moore
- J. R. Hess
- M. E. Ledford