Delayed Resuscitation with Hypertonic Saline/Dextran from Uncontrolled Aortotomy Hemorrhage in Swine
Abstract
Immediate resuscitation from hemorrhage, a common therapy in clinical practice, is associated with high mortality in laboratory models of uncontrolled hemorrhage. We hypothesized that a delayed resuscitation might improve survival, and that gradual repletion of vascular volume might be the most beneficial treatment. To investigate delayed resuscitation, we subjected anesthetized swine weighing 35 to 45 kg to wire suture abdominal aortotomy which resulted in an uncontrolled hemorrhage. After a 30 min delay, they were injected with 4 ml/kg intravenous hypertonic saline/dextran solution (7.5% saline in 6% Dextran 70) administered either as a bolus over 1 minute or as a slow infusion over 12 minutes. Survival was enhanced to 63%, 5/8, in the bolus groups and 78%, 7/9, in the slow infusion group over a survival rate of 57%, 8/14, in the untreated controls. These differences in survival were not statistically significant based on the chi-square test
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 29, 1993
- Accession Number
- ADA266475
Entities
People
- John D. O'benar
- Stephen P. Bruttig
Organizations
- Letterman Army Hospital