Neuropeptide-Y (NPY) Increases Total Blood Flow in the Tail, and Reduces Cutaneous Microvascular Blood Flow in the Tail and Foot of the Rat
Abstract
The purpose of this study was to describe the in vivo effects of neuropeptide-Y (NPY) on total blood f low (BF sub T) and on microvascular skin blood flow (BF sub sk) in appendages of a whole animal model. This study is important to understanding the medical relevance of NPY in cardiovascular physiology. The tail and foot of the rat were used as the model. BF sub sk and skin temperature (T sub sk) were measured on the foot pad and mid-way along the tail with a laser Doppler flowmeter and a 40-gauge thermocouple. BF sub T was measured mid-way along the tail (distal to the laser Doppler flowmeter) via venous occlusion plethysmography. NPY (16, 32, 64 and 128 microgram/kg), norepinephrine (NE) (25, 50, 100, and 400 microgram/kg) , or saline alone was administered i.v. in 300 microliter volume. NE caused marked reductions in blood flow at all three sites. The duration of the contraction was correlated with the dose. NPY caused immediate marked decreases
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 10, 1993
- Accession Number
- ADA266839
Entities
People
- Jomin Thomas
- M. E. Heath
Organizations
- Naval Medical Research Center