Chemoselective Reactions of Functionalized Piperidines

Abstract

The reduction-oxidation strategy for transformation of a cyano function into a carbomethoxy function was investigated as an alternative to the well-studied hydrolysis routes for viability with alpha-aminonitrile 2. Chemoselectivity problems were minimized when the reduction was effected with diisobutylaluminum hydride under inverse addition conditions.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 1993
Accession Number
ADA267002

Entities

People

  • C. G. Cho
  • G. H. Posner
  • H. D. Banks

Organizations

  • Edgewood Chemical Biological Center

Tags

Communities of Interest

  • C4I

DTIC Thesaurus Topics

  • 1-Ring Heterocyclic Compounds
  • Aldehydes
  • Alkanes
  • Analgesia
  • Analgesics
  • Anhydrides
  • Carboxylic Acids
  • Chemical Compounds
  • Chemical Synthesis
  • Chemistry
  • Engineering
  • Materials
  • Morphine
  • Opioids
  • Organic Chemistry
  • Organic Compounds
  • Silica Gels

Readers

  • Adaptive Control and Estimation with Uncertainty in Dynamic Systems.
  • Organic Chemistry