Novel Approaches to the Synthesis of Carfentanil
Abstract
Three novel approaches to the synthesis of carfentanil were investigated that did not involve the hydrolysis of the corresponding a- aminonitrile. Starting with commercially available 1-benzyl-4-piperidone, regioselective cleavage of an a,B-exoxysulfone, an aza (3.3) sigmatropic rearrangement and aminolysis of a 1-bromo-1,2-diene were studied. Of these, the most promising was the sigmatropic rearrangement.... Carfentanil, Aza sigmatropic rearrangement, Piperidine.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1993
- Accession Number
- ADA267058
Entities
People
- Bertrand O. Fraser-reid
- Harold D. Banks
- Kalula Taba
Organizations
- Edgewood Chemical Biological Center