Immunogenicity and Efficacy of a Heat-Killed Whole Cell/B Subunit Cholera Vaccine
Abstract
(1) To confirm the safety of a WC/rBS cholera vaccine in non-immune US adults, (2) to demonstrate serum immunoglobulin type G and fecal secretory immunoglobulin type A to the antigens used when administered in two oral doses, (3) to establish the efficacy of the WC/rBS vaccine against naturally occurring enterotoxigenic E. coli infection in U.S. adults in Mexico with a comparison between the two study groups of the following endpoints: rates of enterotoxigenic E. coli due to heat-labile (LT) and heat-stable (ST) enterotoxin producing strains during a 5-week period, timing of protection in relationship to vaccine administration, and relationship between enterotoxigenic E. coli diarrhea attack rates and serum IgG as well as fecal IgA antibody responses.... RAI, Cholera vaccine, Volunteers, Enterotoxigenic E. Coli, Recombinant vaccine, ID, Diseases, Biotechnology.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 15, 1993
- Accession Number
- ADA267174
Entities
People
- Herbert Dupont
Organizations
- University of Texas Health Science Center at Houston