Phosphoprotein Regulation of Synaptic Reactivity

Abstract

The regulation of synaptic reactivity by protein kinase C and its substrate proteins has been studied using both behavioral and long-term potentiation (LTP) paradigms. We have studied the effects of protein kinase C activators and inhibitors on the durability of. synaptic reactivity. The main conclusion to be drawn is that protein kinase C plays a pivotal and indeed necessary role for enhanced durability. In combination with a neural signal, PKC demonstrates a profound synergism enhancing synaptic efficacy.

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Document Details

Document Type
Technical Report
Publication Date
Jul 07, 1993
Accession Number
ADA268145

Entities

People

  • Aryeh Routtenberg

Organizations

  • Northwestern University

Tags

Communities of Interest

  • Space

DTIC Thesaurus Topics

  • Alzheimer Disease
  • Biological Sciences
  • Brain
  • Cells
  • Cellular Structures
  • Chemistry
  • Diseases And Disorders
  • Enzyme Inhibitors
  • Fatty Acids
  • Ionic Current
  • Medical Personnel
  • Nervous System
  • Neurosciences
  • Nucleotides
  • Proteins
  • Synapses

Fields of Study

  • Biology

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Neuroscience