Free-Radical Yields in Proton Irradiation of Oriented DNA: Relationship to Energy Transfer Along DNA Chains
Abstract
Spatial patterns of energy deposition on the nanometer scale are currently believed to be a major factor in determining the biological effectiveness of ionizing radiation. If the most common precursors of biologically significant lesions are clusters of ionization in or near DNA, then intramolecular energy and charge transfer along DNA chains could be very important in lesion development. This paper describes investigations of these phenomena through model calculations and measurements of radical yields in oriented DNA exposed to proton irradiation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1993
- Accession Number
- ADA268663
Entities
People
- C. E. Swenberg
- D. L. Frasco
- Jacob H. Miller
- L. S. Myers Jr.
- M. Ye
Organizations
- Armed Forces Radiobiology Research Institute