Kinetics of Nitrogen Oxide Production Following Experimental Thermal Injury in Rats,

Abstract

Nitric oxide is biosynthesized from the amino acid l-arginine by the enzyme nitric oxide synthase. Nitric oxide is a vasodilator, a neurotransmitter, and may modulate immune function. The experiments presented here were performed to determine whether the synthesis of nitric oxide is increased following experimental burn injury in rats. After a 30% total body surface area burn in 300-g Lewis rats, the urinary output of nitrate, a stable metabolite of nitric oxide, was significantly increased for 8 days postburn compared with that in sham-burned control rats. The origin of the urinary nitrate from L-arginine was demonstrated by administering the stable isotope 15 N2-guanido-arginine to burned and sham-burned rats and observing an immediate enrichment of 15 N in nitrate.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1993
Accession Number
ADA268669

Entities

People

  • Albert T. Mcmanus
  • Arthur D. Mason Jr.
  • Basil A. Pruitt Jr.
  • Ronald L. Shippee
  • William K. Becker

Organizations

  • United States Army Institute of Surgical Research

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Blood
  • Brain
  • Burns
  • Cardiovascular Physiological Phenomena
  • Cells
  • Central Nervous System
  • Chemistry
  • Drinking Water
  • Gastrointestinal Diseases
  • Infection
  • Kinetics
  • Macrophages
  • Nervous System
  • Nitrogen Oxides
  • Wound Infections
  • Wounds And Injuries

Fields of Study

  • Biology
  • Chemistry

Readers

  • Cardiovascular Physiology
  • Thin Film Deposition Science.
  • Trauma Surgery or Emergency Medicine.