Effects of Pharmacologic Intervention on Oxygenation, Lung Water and Protein Leak in the Pseudomonas ARDS Procine Model
Abstract
Adult respiratory distress syndrome (ARDS) is an explosive form of acute respiratory failure, most commonly seen in critically-ill patients (Byrne et al. 1987). It is characterized by clinical respiratory distress, marked hypoxemia refractory to increased F1O2 and, bilateral infiltrates on chest x-ray in the absence of increased left atrial filling pressures. Histologically, ARDS is characterized by engorgement of pulmonary capillaries with inflammatory cells and the presence of large amounts of hyaline material in the alveoli with evidence of widespread injury to the alveolar-capillary membrane. It is this latter feature of diffuse alveolar-capillary membrane injury with consequent increased permeability pulmonary edema which distinguishes ARDS from other causes of acute respiratory failure, such as acute alveolar hypoventilation due to respiratory center depression or neuromuscular disease, acute hypoxemia associated with congestive cardiac failure, reduced functional residual capacity, commonly seen in the post-operative surgical patient, severe asthma, pulmonary embolism and bacterial pneumonia. RAII, Lab animals, Pigs, Volunteers, Acute respiratory distress, Capillary permeability, Swine
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1993
- Accession Number
- ADA268720
Entities
People
- Alastair C. Windsor
- Ciaran J. Walsh
- Kari Byrne
- P. D. Carey
- Patrick G. Mullen
Organizations
- Virginia Commonwealth University School of Medicine