A Practical, Convergent Method for Glycopeptide Synthesis
Abstract
This research involves the synthesis and analysis of models of glycoprotein folding. These models are glycopeptides. Glycopeptides are extremely difficult to synthesize using existing technology. Therefore, the bulk of our effort has been expended in an effort to develop a practical method for the synthesis of these molecules. The method that we have developed is simple, uses commercially available materials and is extremely economical. We have used this method to prepare complex glycopeptides which are derived from natural glycoprotein structures. The analysis of these materials is underway using solution NMR techniques.... Peptide, Glycopeptide, Glycoprotein, Peptide synthesis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 23, 1993
- Accession Number
- ADA268904
Entities
People
- Peter T. Lansbury Jr.
Organizations
- Massachusetts Institute of Technology