Structure/Activity Effects for Oligomeric and Polymeric p-Nitrophenyl Esterases
Abstract
Duplication of enzymic efficiency and selectivity with synthetic materials has been the goal of much research. Studies directed toward understanding enhancement of amide and ester hydrolysis frequently utilize p- nitrophenyl esters of alkonoic acids, 1 as substrates to gain mechanistic insight (eq. 1). Most studies have focused on increasing efficiency through use of highly reactive catalytic sites, separately or in conjunction with covalently organized binding sites. Our goal has been to examine structure/activity relationships in linear, polymeric catalysts that self-organize in aqueous medium to form binding sites that function cooperatively with efficient catalytic groups in hydrolysis of 1.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1993
- Accession Number
- ADA268964
Entities
People
- Martel Zeldin
- Slawomir Rubinsztajn
- Wei Chen
- Wilmer K. Fife