Models of Glycoprotein Folding

Abstract

This research involves the synthesis and analysis of models of glycoprotein folding. These models are glycopeptides. Glycopeptides are extremely difficult to synthesize using existing technology. Therefore, the bulk of our effort has been expended in an effort to develop a practical method for the synthesis of these molecules. The method that we have developed is simple, uses commercially available materials and is extremely economical. We have used this method to prepare complex glycopeptides which are derived from natural glycoprotein structures. The analysis of these materials is underway using solution NMR techniques.

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Document Details

Document Type
Technical Report
Publication Date
Jul 23, 1993
Accession Number
ADA269071

Entities

People

  • Peter T. Lansbury Jr.

Organizations

  • Massachusetts Institute of Technology

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Aspartic Acid
  • Biomedical And Dental Materials
  • Carbohydrates
  • Chemical Compounds
  • Chemical Synthesis
  • Chemistry
  • Glycoconjugates
  • Glycoproteins
  • Materials
  • Molecules
  • Organic Chemistry
  • Polymeric Films
  • Polysaccharides
  • Resins
  • Sugars

Fields of Study

  • Chemistry

Readers

  • Nanocomposite Materials Science
  • Systems Analysis and Design
  • Virology (or Medical Virology).