Proteins of Human Immunodeficiency Virus That Cross-React with Human Self Antigens
Abstract
HIV causes a persistent infection that results in AIDS, a major health to military and civilian populations we have and continue to study both arms of the immune system -- one that produces antibodies and one that makes cytotoxic T lymphocytes (CTL). Our purpose is two-fold. First, to determine which is important, or more essential, in producing immunity. This data should be essential for vaccine production to that end we have evaluated CTL activity in selected patients from the onset of HIV infection and through their clinical course. Second, to determine the role of antibody and/or CTL in contributing the disease. Toward that end we have defined, in three separate HIV-1 infected individuals, monoclonal antibodies that react with gp4l aa644-663, but also binds to a novel antigenic determinant on mammalian astrocytes.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 20, 1993
- Accession Number
- ADA269185
Entities
People
- Michael B. Oldstone
Organizations
- Scripps Research