Production of Reactive Oxygen Species by Polyhalogenated Cyclic Hydrocarbons (PCH)

Abstract

During the past three years, excellent progress has been made relative to the specific objectives of this project. The results strongly support the hypothesis that the ability of polyhalogenated cyclic hydrocarbons (PCH) to induce production of reactive oxygen species may contribute to many of the toxic manifestations associated with these xenobiotics. As a consequence of the studies, seven papers have been presented at national and international meetings. In addition, twelve manuscripts have been published, three manuscripts are in press, and one manuscript has been submitted. Furthermore, several manuscripts are in the process of being written. Copies of the reprints and manuscripts are appended.

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Document Details

Document Type
Technical Report
Publication Date
Jun 14, 1993
Accession Number
ADA269354

Entities

People

  • Sidney J. Stohs

Organizations

  • Creighton University

Tags

DTIC Thesaurus Topics

  • 1-Ring Heterocyclic Compounds
  • Carbon Tetrachloride
  • Cells
  • Chlordane
  • Cyclic Hydrocarbons
  • Formaldehyde
  • Free Radicals
  • Hydrocarbons
  • Immune System
  • Liquid Chromatography
  • Macrophages
  • Mass Spectrometry
  • Membrane Fluidity
  • Metabolism
  • Oxidative Stress
  • Tissues
  • Vitamin E

Fields of Study

  • Environmental science

Readers

  • Neurotoxicology
  • Polymer Science and Engineering.
  • Technical Research and Report Writing.