Liquid Collagen Wound Coverings

Abstract

One of the major difficulties with the application of growth factors to accelerate wound healing is that to date there is no way to deliver the growth factor(s) constantly over a prolonged time. This would, we propose, greatly enhance the effect of the growth factor. We have developed a DOPA crosslinked type I collagen material and an iodine gelled type I collagen would dressing for such purposes. These are several techniques by which we are attempting to determine the feasibility of using these collagen-based materials as a delivery vehicle for growth factors, both in vitro and in vivo. These natural delivery vehicles have many advantages, including rapid gelling, moldability, good tensile strength no immunoreactivity (the collagen has been isolated by pepsin digestion), and their potential as slow-release vehicles. This preliminary study has concentrated on fibroblast growth factor FGE, as a model growth factor since it has been studied extensively and has been shown to enhance wound healing when applied topically in a liquid vehicle

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Document Details

Document Type
Technical Report
Publication Date
Sep 02, 1993
Accession Number
ADA269457

Entities

People

  • J. P. Bentley

Organizations

  • Oregon Health & Science University

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Blood Vessels
  • Cartilage
  • Cells
  • Collagen
  • Combat Casualty Care
  • Fibroblasts
  • Growth Factors
  • Health Services
  • Materials
  • Mechanical Properties
  • Military Research
  • Molecular Biology
  • Technical Information Centers
  • Tensile Strength
  • Tissues
  • Wound Healing

Readers

  • Molecular and Cellular Biochemistry
  • Polymer Science and Engineering.
  • Trauma Surgery or Emergency Medicine.