Platelet-Activating Factor (PAF)-Induced Cardiopulmonary Dysfunctions and their Reversal with a PAF Antagonist (BN 52021) in Strain 13 Guinea Pigs
Abstract
Cardiovascular and respiratory responses to a 2 h intravenous constant infusion of PAF were studied in strain 13 guinea pigs. PAF decreased arterial blood pressure, left systolic ventricular pressure, and cardiac output (CO). These cardiovascular changes were dose-dependent. The PAF-induced hypotension returned to a pre-infusion level spontaneously with increased total peripheral resistance despite continuous infusion of PAF. The decreased CO was most striking, and did not recover to pre-infusion levels due to depressed cardiac contractility and impaired ventricular relaxation. Respiratory responses to PAF infusion at these doses were mild and only occurred after serious cardiovascular dysfunctions developed. A higher dose of PAF produced drastically decreased CO and dynamic lung compliance increased pulmonary airway resistance, hypoventilation and apnea within 10-40 min. BN 52021, a PAF receptor antagonist, administered as a single i.v. dose (6 mg/kg) 15 min after PAF infusion, reversed most of cardiopulmonary dysfunctions and prevented death by increasing cardiac contractility, CO, and minute volume from extremely low values.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1993
- Accession Number
- ADA269618
Entities
People
- Changgeng Qian
- Ching-tong Liu
- Clarence J. Peters
- Zhong-mao Guo
Organizations
- United States Army Medical Research Institute of Infectious Diseases