Mechanisms of Cytotoxicity of the Aids Virus
Abstract
Regulatory genes of HIV-1, HIV-2, and SIV are important in modulating virus infection and infection and transmission in vivo. Viral proteins R (VPR) and X (VPX) and the negative factor-(NEF) are three of the least well characterized regulatory proteins. Identification of their functions, their mechanisms of actions, and structure-function relationships of each protein, in vitro and in vivo will assist in our understanding of the pathogenesis of HIV- induced disease. This information will be critical in defining therapeutic approaches to suppression HIV-1 infection, replication, and transmission. VPR, VPX, NEF, HIV-1, VPU, AIDS, Cytotoxicity, Biology, Biotechnology, RAD I
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 10, 1992
- Accession Number
- ADA269769
Entities
People
- Lee Ratner
Organizations
- University of Washington