Presynaptic Modulation of the Hippocampal Mossy Fiber Synapse
Abstract
The overall goal of this research project was to systematically investigate a number of the possible ways through which presynaptic modulation might influence the effectiveness of local synaptic interactions at the mammalian hippocampal mossy fiber synapse. Work conducted during this period of support resulted in the publication of 20 peer-reviewed research articles and 19 abstracts. These funds also supported the research training of 7 doctoral students, 1 masters student, 2 medical students and 1 high school student. A hippocampal subcellular fraction that is highly enriched in large mossy fiber nerve endings was developed as a model system for investigating the presynaptic modulation of the hippocampal mossy fiber system. The morphological and metabolic properties of this synaptosonal preparation were described in detail and have been independently verified (Ueda et al., 1992, Eur. J. Pharmacol. 219- :271-277). We were the first to demonstrate that both glutamate and prodynorphin-derived peptides are co-released from these unusually large nerve endings in response to membrane depolarization by calcium dependent mechanisms. Presynaptic, Hippocampus, Mossy fiber, CA3, Glutamate, Dynorphin, Protein kinase C.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1993
- Accession Number
- ADA269935
Entities
People
- David M. Terrian
Organizations
- East Carolina University