Synthesis and Antimalarial Activity of Some 9-Substituted Artemisinin Derivatives
Abstract
Several 9-substituted derivatives of the antimalarial drug artemisinin have been prepared by functionalizing the double bond-6f artemisitene and related compounds. Stereochemical assignments for these compounds were made using a combination of NMR experiments, an X-ray diffraction study of one compound and chemical correlations of several other compounds with this one compound of unambiguous structure and with its epimer. The compounds synthesized show a wide variation in in vitro antimalarial activity. Antimalarial activity, Artemisitene, Nuclear magnetic resonance, X-Ray diffraction.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 20, 1993
- Accession Number
- ADA270011
Entities
People
- James M. Karle
- Nancy Acton
- Robert E. Miller
Organizations
- Walter Reed Army Institute of Research