Vaccine Therapy for HIV: A Historical Review of the Treatment of Infectious Diseases by Active Specific Immunization with Microbe-Derived Agents
Abstract
A review of the history of vaccine therapy for infectious diseases is presented. The concept originated when Auzias-Turenne introduced syphylitic vaccination as a treatment for syphilis in Paris in the mid-1800s; his clinical studies probably influenced Pastuer's successful rabies postexposure vaccine trials. Robert Koch in Berlin in the 1890s observed that innoculation of tuberlculin into patients with tuberculosis induced an inflammatory response in affected tissues, and advocated tuberculin therapy . Sir Almoth Wright in the early 20th century devised methods to measure changes in serum opsonizing activity in response to therapeutic innoculations with microbe-derived vaccines. Advances in antigen production and in molecular immunology now permit new tactics to probe, analyse and selectively alter in vivo human immune responses to infectious microbes. Our recent demonstration that vaccine therapy can boost natural immunity to HIV infection should rekindle interest in this approach. Vaccine therapy, HIV, Microbe-derived antigens.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1993
- Accession Number
- ADA270014
Entities
People
- Donald S. Burke
Organizations
- Walter Reed Army Institute of Research