The Pharmacology of p-Aminopropiophenone in the Detoxification of Cyanide

Abstract

PAPP is effective as a pretreatment antidote to cyanide when used by single-dose administration. Further experiments need to be performed to establish a lack of toxicity of PAPP in multiple-dose experiments. Possible chronic hematological and genotoxic effects of PAPP may limit its development in repeated chronic treatment. Combination therapy of a prophylactic sulfur donor with a low dose of a safer prophylactic aminophenone (e.g., PAOP or p- aminoheptanoylphenone or their N-hydroxy metabolites) may provide more efficacious protection against cyanide than PAPP. This combination could allow for a reduction in the dosage of MetHb formers that would reduce the chance of unwanted side effects of the employed therapeutic compounds.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1992
Accession Number
ADA270793

Entities

People

  • Robert F. Fricke
  • Steven I. Baskin

Organizations

  • United States Army Medical Research Institute of Chemical Defense

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Birds
  • Blood
  • Cardiovascular Drugs
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Cyanides
  • Health Services
  • Hematologic Diseases
  • Hemoglobin
  • Medical Personnel
  • Rodents
  • Sodium Compounds
  • Therapy
  • Toxicity

Fields of Study

  • Medicine

Readers

  • Toxicology/Environmental Toxicology