Pharmacological Dissociation of the Motor and Electrical Aspects of Convulsive Status Epilepticus Induced by the Cholinesterase Inhibitor Soman
Abstract
In an effort to validate methods to be used in a screen for drugs effective as anticonvulsants for soman-induced convulsions, scopolamine (0.2 mg kg) or diazepam (1 mg kg) were given (i.m.) to male guinea pigs as a pretreatment 30 min before a convulsant dose of soman. Pyridostigmine, atropine and pralidoxime chloride also were given to counteract the lethality of soman. All animals challenged with soman and which did not receive either diazepam or scopolamine exhibited convulsive status epilepticus (SE), identified by continuous electrographic seizure active (EGSA) and continuous motor convulsions. Despite the presence of continuous motor convulsions in all animals pretreated with diazepam and challenged with soman. EGSA was not observed in five of the seven animals.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1993
- Accession Number
- ADA270795
Entities
People
- Everette T. Beers
- Lucas H. Brennecke
- Steven Sparenborg
Organizations
- United States Army Medical Research Institute of Chemical Defense