A Study of the Effect of Hydrocarbon Structure on the Induction of Male Rat Nephropathy and Metabolic Structure
Abstract
Certain hydrocarbons have been shown to cause nephrotoxicity in male rats. Since many of the hydrocarbons have a branched alkyl side chain, several isomers of octane including 2,5-dimethylhexane. 2-methylheptane, 3-methylheptane and 4-methylheptane were evaluated on their ability to induce the nephrotoxicity. Since the above hydrocarbons are components of fuels and solvents, an investigation into their pathways of metabolism was undertaken in order to see if a pattern of biotransformation could be deduced and determined if potentially harmful metabolites were produced. Male 344 Fischer rats were dosed intragastrically with the above hydrocarbons over a 14 day period.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 31, 1993
- Accession Number
- ADA270969
Entities
People
- M. P. Serve'
Organizations
- Wright State University