Non-Ionic Surfactants in the Treatment of Third Degree Burns.
Abstract
Pluronic polyols are non-ionic surfactants developed in the 1950's. They are block co-polymers or the ABA type where A is made up of ethylene oxide polymers and B is propylene oxide polymers. They differ only in their molecular weight. The Pluronic polyols have been shown to be non-toxic. This protocol evaluates their effect on third degree scald burn in a rat model, pluronic polyols were administered 30 minutes following a third degree scald burn to the chest of 300-320 gram male rats. Histological evaluation documented this burn. The Pluronic polyol was administered intravenously at a concentration of 12mm/1 with a dose of 8ml/kg body weight. Animals were followed for four weeks (complete healing)
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1993
- Accession Number
- ADA271582
Entities
People
- James C. Mcpherson