Immunologic Intervention in HIV Infection: Anti-Polymerase Responses and Hormonal Regulation
Abstract
This work represented an integrated effort to develop novel Pol-based immunogens, and to explore mechanisms of enhancing the efficacy of both HIV immunogens and antivirals through use of peptide hormone. With the past three years of DAMD support, we have defined epitopes of HIV-1 polymerase (Pol) which correlate with serum IgG-mediated inhibition of Pol catalytic activity and limited progression of HIV disease. As Pol exhibits restricted variability and elicits potent T cell proliferative, cytotoxic and humoral responses, these regions might be considered for inclusion as candidates in peptide-based or peptide-boosted, recombinant protein-based protective and immunotherapeutic vaccines. Second, recent elucidation of certain properties of recombinant human growth hormone (rhGH) suggests direct relevance to AIDS vaccines and immunotherapeutics. rhGH markedly enhances proliferation of engrafted human CD4+ and CD8+ T cells in SCID/hu mice, and counteracts hematopoietic suppression in animals treated with AZT.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1993
- Accession Number
- ADA271869
Entities
People
- Jeffrey Laurence
Organizations
- Cornell University