Evaluation of Cytotoxic Activity in Fecal Filtrates from Patients with Campylobacter jejuni or Campylobacter coli enteritis
Abstract
Although Campylobacter jejuni and C. coli are important causes of diarrheal illness worldwide, the pathophysiologic mechanisms whereby these organisms cause human disease remain poorly understood (1). Cytotoxic activity has been demonstrated in culture supernatants of C. jejuni and C. coli grown in vitro (2-7), but the in vivo relevance of these observations is not clear. We therefore sought to detect cytotoxic activity in fecal filtrates from persons with campylobacter enteritis. Fecal filtrates from persons with diarrhea due to other causes and from asymptomatic healthy persons were tested as controls.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1990
- Accession Number
- ADA271880
Entities
People
- Guillermo I. Perez-perez
- Martin J. Blaser
- Timothy L. Cover
Organizations
- Veterans Administration Medical Center