Effect of Photoperiod on Blood Cholinesterase Activity and Melatonin Concentrations in Adult Cats

Abstract

Activity of synaptically released acetylcholine (Ach) is terminated by the degradative enzyme acetylcholinesterase (AChE), or true cholinesterase. There is a second class of cholinesterase found in living systems, pseudocholinesterase (butyrylcholinesterase, BUChE) which preferentially hydrolyzes higher choline esters. Some of our previous studies with cholinesterase inhibitors relate decrements in the visual evoked response (VER) to inhibition of AchE or BUChE. Initial decrements in the VER appear to be related to blood activity of cholinesterases. In addition to AchE inhibition, other neurochemical alterations have been reported after exposure of animals to organophosphate (OP).

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1993
Accession Number
ADA273107

Entities

People

  • Albert W. Kirby
  • Alfred T. Townsend
  • Carolyn D. Pope
  • George Evans

Organizations

  • United States Army Aeromedical Research Lab

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Air Force
  • Air Force Facilities
  • Biological Sciences
  • Biomedical Research
  • Blood
  • Brain
  • Health Services
  • Jugular Vein
  • Liquid Chromatography
  • Medical Personnel
  • Military Research
  • Nervous System
  • Secretion
  • Veins

Readers

  • Circadian Sleep-Wake Regulation and Chronobiology
  • Neuroscience
  • Neurotoxicology