The 3D Structure of Staphylococcal Enterotoxins

Abstract

The overall objective is to determine the crystal structures of the staphylococcal enterotoxins. The 3D structure of SEB has been determined and functional sites on the molecule have been identified. Efforts are underway currently to purify and to crystallize other members of the family, particularly SEA and SEB. The mode of binding of the latter two to MHC class II molecules differs from that of SEB, and this implies a difference in 3D structure could be a likely possibility, although the overall main chain fold of the entire family is expected to be the same. Refinements are in progress on a mitant of SEB and on another polymorph of SEB. Staphylococcal enterotoxins, 3D structures, X-ray diffraction, Protein crystallography, Superantigen, Toxins, Enterotoxins, BD, BL2, RAD IV

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Document Details

Document Type
Technical Report
Publication Date
Oct 15, 1993
Accession Number
ADA273248

Entities

People

  • Martin Sax

Organizations

  • Veterans Administration Medical Center

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Antigens
  • Bacterial Toxins
  • Biological Toxins
  • Biomedical And Dental Materials
  • Biomedical Research
  • Chemistry
  • Crystal Structure
  • Crystallography
  • Crystals
  • Diffraction
  • Electron Density
  • Food Poisoning
  • Lymphocytes
  • Materials
  • Molecules
  • X Rays
  • X-Ray Diffraction

Fields of Study

  • Chemistry

Readers

  • Immunology
  • Materials Science and Engineering.
  • Molecular and Cellular Biochemistry