Preerythrocytic Malaria Vaccine Development
Abstract
In the 1940s, Mulligan and colleagues demonstrated that immunization of chickens with radiation-attenuated Plasmodium gallinaceum sporozoites induced protective immunity. In the late 1960s, Nussenzweig and colleagues demonstrated that immunization of A/J mice with radiation-attenuated P. berghei sporozoites protected mice against challenge with live sporozoites. This immunity was stage specific; mice challenged with infected erythrocytes were not protected. In the early 1970s Clyde and colleagues and Rieckmann and colleagues demonstrated that immunization of humans by the bite of irradiated Anopheles sp. mosquitoes carrying P. falciparum and one case P. vivax sporozoites in their salivary glands protected these volunteers against challenge with live sporozoites.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1993
- Accession Number
- ADA274466
Entities
People
- Eileen D. Franke
- Stephen L. Hoffman
- Sylvie Mellouk
- William O. Rogers
Organizations
- Naval Medical Research Center