Absence of True Seroreversion of HIV-1 Antibody in Seroreactive Individuals
Abstract
This study had two objectives: first, to determine whether there is evidence for loss of human immunodeficiency virus type l(HIV-1) antibody in serreactive individual Second, if true seroreversion occurs, to determine its incidence relative to error in the testing process. A retrospective cohort study reviewing the results of 5,446,161 HIV-1 antibody tests performed on 2,580,974 individuals(US ARMY HIV data system) from 1985 thru 1992. For all patients with one or more seroreactive sample followed by one or more nonreactive sample, we examined the available records and retested the samples. Serum samples had been obtained from active-duty and retire military personnel, their dependents, and applicants to the military. Review of this database demonstrates no evidence for true seroreversion of HIV-1 antibody status. We conclude that if seroreversion occurs at all, it is exceedingly rare. In fact, most(if not all) cases of apparent seroreversion represent errors of attribution or testing.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 09, 1993
- Accession Number
- ADA274577
Entities
People
- Donald S. Burke
- James J. Damato
- Michael J. Roy
Organizations
- Walter Reed Army Institute of Research