Pathobiology of HIV in the Human Monocyte-Macrophage
Abstract
In the past year, we have made considerable progress in pursuing the specific aims of our proposal. We have investigated interaction of HIV with monocyte-macrophages. We have successfully identified responsive elements in the long terminal repeat (LPR) of HIV which interact with steroid hormone receptors that function as transcription factors. Importantly, we have characterized the differential response in monocyte-macrophages compared to T cells which depends upon expression of such receptors. In addition, we have begun to pursue transduction of monocyte-macrophages using the adeno-associated virus vector system for purposes of introducing anti-HIV gene.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 03, 1993
- Accession Number
- ADA274725
Entities
People
- Jerome E. Groopman
Organizations
- Beth Israel Deaconess Medical Center