A Pharmacological Profile of Glycopyrrolate: Interactions at the Muscarinic Acetylcholine Receptor

Abstract

Glycopyrrolate, a synthetic quaternary ammonium compound had biphasic effects on the contraction of guinea-pig atrium. At concentrations between 0.4 and 20 microM, glycopyrrolate induced a small but consistent increase in the contraction force. Our results confirm the antimuscarinic properties of glycoprrolate. We suggest that the therapeutic value of glycopyrrolate in treatment of organophosphate poisoning is associated with its potency against prolonged muscarinic receptor activation by cholinergic agonists.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1992
Accession Number
ADA274877

Entities

People

  • Maria Szilagyi
  • Wai-man Lau

Organizations

  • Defence Science and Technology Group

Tags

DTIC Thesaurus Topics

  • Ammonium Compounds
  • Anesthesia
  • Atropine
  • Australia
  • Brain
  • Buildings And Structures
  • Cerebellum
  • Combination Therapy
  • Contrast
  • Enzyme Inhibitors
  • Filter Paper
  • Inhibition
  • Materials
  • Membranes
  • Poisoning
  • Rodents
  • Therapy

Fields of Study

  • Biology

Readers

  • Cardiovascular Physiology
  • Neurotoxicology