Summary Report: Workshop on the Potential Risks of Antibody-Dependent Enhancement in Human HIV Vaccine Trials

Abstract

In several human and animal viral diseases, suboptimal immunity to an infecting agent can cause as adverse or enhanced clinical expression of disease. This phenomenon of immune-mediated disease enhancement can occur on secondary exposure after natural infection, or after virus-specific immunization. In some diseases(e.g. dengue), there is strong evidence that antibody-dependent enhancement(ADE) of infection of monocyte/macrophage(M/M) cells is the pathophysiological mechanism for enhanced disease. In other viral infections, the pathophysiological mechanism is not understood and therefore the term immune-mediated disease enhancement is a more accurate description than ADE.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1993
Accession Number
ADA275482

Entities

People

  • Bonnie J. Mathieson
  • Donald S. Burke
  • John R. Mascola
  • Mary C. Walker
  • Philip M. Zack
  • Scott B. Halstead

Organizations

  • Walter Reed Army Institute of Research

Tags

DTIC Thesaurus Topics

  • Antibodies
  • Blood
  • Cell Line
  • Cells
  • Dengue
  • Encephalitis
  • Genetic Variation
  • Health Services
  • Hiv Infections
  • Immune Serums
  • Lymphatic System
  • Lymphocytes
  • Macrophages
  • Vaccines
  • Virus Diseases
  • Viruses
  • Zoonoses

Fields of Study

  • Biology
  • Medicine

Readers

  • Theoretical Analysis.
  • Virology (or Medical Virology).

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech