Intravital Microscopic Evidence that Polylactide-Polyglycolide (PLGA) delays Neo-Osteogenesis and Neo-Angiogenesis in Healing Bone
Abstract
The bone chamber implant (BCI) has allowed monitoring a healing bone defect as well as the effect of an eroding implant on the healing process. The BCI is a useful tool and intravital microscopy a valuable technique for obtaining quantitative data chronicling osseous wound healing. The physiological parameters that form the initial data base documenting healing are neo- osteogenesis and neo-angiogenesis. This review compares and characterizes osseous wound healing in a BCI loaded with an erodible copolymer, PLGA (polylactide-polyglycolide). To determine if a statistically significant deviation from normal healing had occurred, the results were compared with present and historical controls. In the BCI PLGA erosion was accompanied by a delay in the onset of neo-osteogenesis, as measured by trabecular opposition. Concurrently, neo-angiogenesis was both detained and retarded.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1993
- Accession Number
- ADA275483
Entities
People
- H. Winet
- J. O. Hollinger
Organizations
- United States Army Institute of Surgical Research