Evaluation of Dried Storage of Platelets for Transfusion: Physiologic Integrity and Hemostatic Functionality
Abstract
The work has been proceeding as outlined in the proposal. At UNC- Chapel Hill, the main focus has been on studies in animals, including whole body scans in dogs after infusion of radiolabelled rehydrated canine platelets and assessment of multiple infusions of non-labelled rehydrated platelets. The attached subcontract report from Dr. Read and colleagues shows that the radiolabelled platelets were distributed in the dog(s) in a diffuse pattern when examined 4 hours after infusion. This is a good result, considering that a finding of localized accumulations of infused platelets might have indicated a tendency for spontaneous thrombus formation. The multiple infusion studies have not produced any evidence as yet of an immune reaction to rehydrated homologous platelets (up to 7 infusions in same animal); however, earlier experiments showed that it was necessary to change from bovine serum albumin in the preparation to canine albumin to avoid an immediate allergic reaction.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 1993
- Accession Number
- ADA276018
Entities
People
- Arthur P. Bode
- Marjorie S. Read
- Robert L. Reddick
Organizations
- East Carolina University