Association of Low Serum Concentration of Bilirubin with Increased Risk of Coronary Artery Disease
Abstract
We examined serum bilirubin and various liver-function enzymes as possible risk factors for angiographically documented coronary artery disease (CAD). The studies involved a training set of 619 men for whom complete data on all risk factors considered were available, and a test set of 258 men for whom some risk factor data were not available. In both study groups, the liver enzymes were not related to CAD; however, In (total bilirubin) was inversely and statistically significantly related to the presence of CAD, both univariately and multivariately after adjustment for the established risk factors of age, total cholesterol, high-density lipoprotein cholesterol, smoking history, and systolic blood pressure. A 50% decrease in total bilirubin was associated with a 47% increase in the odds of being in a more severe CAD category. Our data suggest that serum bilirubin is an inverse and independent risk factor for CAD, with an association equivalent in degree to that of systolic blood pressure. Coronary artery disease, Heart disease, Lipids, Lipoproteins, Risk factors.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1994
- Accession Number
- ADA276272
Entities
People
- Gil Tolan
- Harvey A. Schwertner
- William G. Jackson
Organizations
- Armstrong Laboratory