Amino Acid Neurotransmitters and High Pressure Nervous Syndrome

Abstract

High pressure nervous syndrome (HPNS) occurs in humans and animals exposed to high atmospheric pressures such as those experienced during deep diving. The primary symptoms of HPNS, which are tremors and seizures, may result from excessive excitatory or inhibitory neurotransmission in the central nervous system. This project comprised two components. The first was a detailed study of the mechanisms by which excitatory and inhibitory transmitters are released from astroglial cells in vitro and the effects of high pressure on these processes. The second component was the analysis of amino acids (specifically including glutamate, aspartate, taurine, and gamma-aminobutyric acid) of perfusion fluids and tissue extracts received from the Hyperbaric Medicine Program Center, NMRI, Bethesda, MD.

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Document Details

Document Type
Technical Report
Publication Date
Jan 07, 1991
Accession Number
ADA277669

Entities

People

  • David L. Martin

Organizations

  • New York State Department of Health

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Amino Acids
  • Astrocytes
  • Barometric Pressure
  • Cell Membrane
  • Cells
  • Central Nervous System
  • Computer Programs
  • High Pressure
  • Hydrostatic Pressure
  • Hyperbaric Medicine
  • Medical Personnel
  • Nervous System
  • New York
  • Osmotic Pressure
  • Peripheral Nervous System
  • Proteins
  • Tissue Extracts

Fields of Study

  • Medicine

Readers

  • Marine Mammal Biology
  • Neuroscience