Variability of Serial Absolute and Percent CD4+ Lymphocyte Counts in Healthy Children Born to Human Immunodeficiency Virus 1-Infected Parents
Abstract
The management of infants and children born to human immunodeficiency virus (HIV-l)-infected mothers is complicated by both the presence of maternal antibody during the first 18 months of life and the normal, physiologic decline of CD4+ cell counts and percentage in infants' 1 / 2 Because early diagnosis of HIV-1 infection in infants and children born to HIV-1-infected mothers is difficult, T cell subset analysis, particularly absolute CD4+ lymphocyte number (CD4 ), has been used to guide decisions regarding the institution of Pneumocystis carinii pneumonia prophylaxis and antiretroviral therapy. 3/4 Although age-specific normal values for T cell phenotypes have been described recently, the power of CD4 to predict the risk for or the development of immunocompromised status is not well-defined except for the advent of P. carinii pneumonia in the first year of life.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1994
- Accession Number
- ADA277810
Entities
People
- David P. Ascher
- Gerald W. Fischer
- Gretchen A. Meyer
- Merlin L Robb
- Norman J. Waecker
- Richard A. Moriarty
- William J. Raszka Jr.
Organizations
- Uniformed Services University of the Health Sciences