Staphylococcal Enterotoxin: Role of Intestinal Immunity in Enterotoxin B Intoxication
Abstract
To investigate the role of intestinal immunity in staphylococcal enterotoxins intoxication. We have chosen the mouse as experimental model, which although resistant to enterotoxins, has a certain advantage by not having an emetic mechanism, thus no loss in peroral administered enterotoxin takes place. Parenteral administration of enterotoxins induced a high titer of specific antibodies in serum, mainly of IgG and IgG2a subclasses. Peroral administration of enterotoxin elicited a good response at the intestinal level as showed by specific anti-enterotoxin antibodies in the supernatants of in vitro cultured intestinal fragments and the synthesized immunoglobulin was IgA. When different routes and combinations of them were studied it was observed that a parenteral followed by peroral administration of enterotoxin induced the higher intestinal immune response. Secretion of specific anti-enterotoxin antibodies by intestinal immune system also lasted longer compared to the presence of antibodies in serum of perorally by immunized animals. Staphylococcus aureus, Enterotoxin B, IgA, Immunity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 1994
- Accession Number
- ADA278229
Entities
People
- A. R. Bhatti
- V. V. Micussan