Cytochemical Organization of the Retino-Suprachiasmatic System
Abstract
In situ hybridization was used to study the ionotropic subtypes of the glutamate receptor in the rat hypothalamus, particularly in the suprachiasmatic nucleus, Widespread expression of AMPA, kainate, and NMDA receptor RNA was found in the hypothalamus. GluRl and GluR2 were among the most strongly expressed of the non-NMDA ionotropic receptors. Other AMPA-preferring receptors, GluR3 and -R4, were also found, but to lesser extent. Scattered cells expressed the kainate-preferring receptors Glu-R5 and -R6. Little GluR7 was found in the hypothalamus. The N-methyl d-aspartate receptor, NMDAR1, was detected throughout the hypothalamus. In many regions of the hypothalamus, only scattered cells showed detectable expression of the glutamate receptor mRNA as detected by autoradiographic silver grains over neurons; unlabeled cells were mixed among labeled cells.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 11, 1994
- Accession Number
- ADA278393
Entities
People
- Anthony N. Van Den Pol
Organizations
- Yale University