Malaria Vaccine Study Site in Irian Jaya, Indonesia: Plasmodium Falciparum Incidence Measurements and Epidemiologic Considerations in Sample Size Estimation
Abstract
Malaria epidemiologic and entomologic studies were performed during both the high transmission and low transmission seasons to characterize the Plasmodium falciparum malaria transmission at a proposed malaria vaccine trial size in Irian Jaya, Indonesia. The study population consisted of two subsets: native Irianese men with lifelong exposure to malaria and transmigrants who arrived from a nonmalarious area 2.5 years before the start of the study. All subjects received a radical cure for malaria and were then monitored weekly by blood film. Both P. falciparum malaria attack rates and incidence densities were calculated: transmigrants had a significantly higher rate (P=0.003) than the Irianese during the low transmission season study (20 weeks long) but not during the high transmission season study (12-weeks long). Lack of exposure-induced immunity left the transmigrants at a minimum 17-25% greater relative risk of becoming parasitemic compared with the Irianese during the low transmission season study.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1994
- Accession Number
- ADA278652
Entities
People
- Barry A. Annis
- Hasan Basri
- J. K. Baird
- Michael J. Bangs
- Trevor R. Jones
Organizations
- Naval Medical Research Center