New Chiral Pyrimidino-Crown Ether Ligands.
Abstract
Two new chiral macrocyclic ligands containing the pyrimidine subcyclic unit (Figure 1) have been prepared. Chiral dimethyl-substituted pyrimidino-crown 1 was prepared from 4-methoxy-5-methyl-2,6-pyrimidinedimethyl ditosylate 3 and chiral dimethyl-substituted tetraethylene glycol. Treatment of dimethyl 4-methoxy-5-methyl-2,6-pyrimidinedicarboxylate 4 with the diamine derivative of chiral dibenzyl-substituted tetraethylene glycol gave the chiral dibenzyl-substituted pyrimidino-crown diamide 2. Starting 4-methoxy-5-methyl-2, 6-pyrimidinedimethanol 11 was prepared by a six step process from acetamidine hydrochloride and diethyl oxalpropionate.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 11, 1994
- Accession Number
- ADA279892
Entities
People
- J. T. Redd
- Jerald S. Bradshaw
- Peter Huszthy
- Reed Izatt
Organizations
- Brigham Young University