Prostaglandin E2 Regulation of Chondrocyte Proliferation and Differentiation
Abstract
Endochondral ossification involves the differentiation of chondrocytes, along with the process of extracellular matrix formation and mineralization by these cells. Vitamin D3 is essential to the regulation of endochondral ossification. The chondrocyte response to vitamin D3 is dependent on the level of cell maturation and the particular vitamin D3 metabolite used. Growth zone chondrocytes respond primarily to 1,25-dihydroxy vitamin D3 and resting zone chondrocytes respond primarily to 24, 25-dihydroxy vitamin D3. Prostaglandin E2 production by growth zone and resting zone chondrocytes is regulated by vitamin D metabolites and is believed to be a mediator between these hormones and their final effect on the cells
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1994
- Accession Number
- ADA281899
Entities
People
- Ridge M. Gilley
Organizations
- Air Force Institute of Technology