Carbon Monoxide Does Not Modulate Pulmonary Vascular Reactivity in Isolated Rat Lungs
Abstract
Recent studies have demonstrated that the gas, nitric oxide (NO), when inhaled in low concentrations acts as a vasodilator in the pulmonary vasculature. Due to the physical and chemical similarities between No and carbon monoxide (CO), we speculated that acute, low concentration exposure to CO would have similar effects in the isolated rat lung. Therefore, the purpose of this study was to determine the role of CO (200 and 1,000 ppm) in modulating hypoxia- and angiotensin II-induced pulmonary vasoconstriction, using isolated salt- perfused (Earle's Salt Solution; + 4 g% Ficoll) lungs of male Sprague Dawley rats (CON). Pulmonary hypertensive rats (ALT), induced by simulated altitude exposure (15,000 ft; 4,572 m; 430 mmhg for 32-48 days) , were also used to determine the effects of CO in a remodeled pulmonary vascular bed
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1994
- Accession Number
- ADA283190
Entities
People
- James M. Cantrell
Organizations
- Air Force Institute of Technology