Study of Compounds for Activity against Leishmania
Abstract
During this project period a total of 41 new compounds were studied for antileishmanial activity against Leishmania donovani in hamsters. Only one had measurable suppressive activity and this compound was toxic. one new compound was studied for efficacy against Leishmania braziliensis panamensis and this compound was not active and was toxic when administered via the intramuscular route. A computer search of a total of 736 compounds that have been tested against L. b. panamensis since 1980 identified a total of 37 compounds with suppressive activity equal to or greater than the standard reference compound, Glucantime. These compounds were then studied in detail to determine the most promising drug and the most promising routes of administration and dosage regimen against L. b. panamensis. For comparative purposes these compounds were tested simultaneously against L. donovani and L. b. panamensis. Leishmania donovani, Leishmania braziliensis panamensis, Chemotherapy, 8-aminoquinolines, Oligonucleotides, Phosphoniums Sinefungin
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 27, 1992
- Accession Number
- ADA283256
Entities
People
- V. B. Waits
- W. L.
- William L. Hanson
Organizations
- University of Georgia