Chemotherapy and Drug Targeting in the Treatment of Leishmaniasis

Abstract

Leishmaniasis, a disease caused by protozoan parasites of the Leishmania spp., is one of the major public health problems currently affecting humanity. Therapeutic agents for this disease is either ineffective or toxic. The purpose of this work is to aid in the development of an effective, non-toxic treatment for leishmaniasis. The objective of this research was to isolate and characterize unique leishmanial enzymes (DNA polymerase) and to test promising antileishmanial compounds for toxicity against human CEM T4 cells.

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Document Details

Document Type
Technical Report
Publication Date
Jan 31, 1993
Accession Number
ADA283541

Entities

People

  • Linda L. Nolan

Organizations

  • University of Massachusetts Amherst

Tags

DTIC Thesaurus Topics

  • Albumins
  • Amines
  • Amino Acids
  • Biomedical Research
  • Cells
  • Chemistry
  • Enzyme Inhibitors
  • Enzyme Kinetics
  • Eukaryotes
  • Leishmaniasis
  • Lymphocytes
  • Materials
  • Metabolism
  • Molecular Weight
  • Protozoa
  • Public Health
  • Sodium Compounds

Fields of Study

  • Medicine

Readers

  • Computational Modeling and Simulation
  • Molecular and genetic basis of cancer.
  • Parasitology and Pharmacology of Malaria.