In Vitro Effect of Sulfasalazine and Its Metabolites on Human T Lymphocyte Activation

Abstract

Sulfasalazine (SF) is an anti-inflammatory sulfonamide used in the treatment of rheumatoid arthritis, ulcerative colitis and ankylosing spondylitis. Its mechanism of action is not fully understood. The possible immunomodulatory role of sufasalazine and its main metabolites, sulfapyridine (SP) and 5-aminosalicylic acid (5-ASA) on T cell activation was analyzed. Peripheral blood mononuclear cells (PBMC) were separated from human blood by Ficoll-Hypaque density gradient centrifugation, depleted of monocytes by plastic adherence and further separated into B and T lymphocytes by the E-rosette method using sheep red blood cells (SRBC).

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1994
Accession Number
ADA283574

Entities

People

  • Richard H. Mcbride

Organizations

  • Air Force Institute of Technology

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Arthritis
  • Autoimmune Diseases
  • Biomedical And Dental Materials
  • Blood
  • Blood Cells
  • Cardiovascular System
  • Cell Membrane
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Colitis
  • Computer Programs
  • Granulocytes
  • Lymphocytes
  • Peptide Growth Factors
  • T Lymphocytes

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology
  • Immunology and Pathology
  • Neurological Diseases/Conditions/Disorders