Sodium Cyanide Increases Cytosolic-Free Calcium; Evidence for Activation of the Reversed Mode of the Na+/Ca2+ Exchanger and Ca2+ Mobilization from Inositol Trisphosphate-Insensitive Pools
Abstract
Cyanide has been shown to affect calcium homeostasis. Cyanide causes an increase in intracellular Ca(2+) concentration in PC12 cells, rabbit carotid body chemoreceptors, rat ventricular myocytes, rat osteoclasts, and Leishmania donovani promastigotes. In PC12 cells the increase is believed to be activated by voltage-gated Ca(2+) channels. In rabbit carotid body chemoreceptors it is due to inhibition of Na(+)/Ca(2+) exchange. In Leishmania donovani promastigotes, it results from a Ca(2+) mobilization from intracellular Ca(2+) pools.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1994
- Accession Number
- ADA283831
Entities
People
- Julian G. Kiang
- Robert C. Smallridge
Organizations
- Walter Reed Army Institute of Research