Cytotoxic T Lymphocytes in Humans Exposed to Plasmodium Falciparum by Immunization or Natural Exposure
Abstract
Malaria is one of the most important infectious diseases in the world. It is estimated that 2.1 billion people live in areas of the world where malaria is transmitted and that there are 100-300 million new cases of malaria and one to two million deaths caused by malaria every year (WHO 1991). In the past 10-20 years, the severity of the malaria problem has worsened in many areas because of the emergence of drug-resistant strains of the parasite, resistance to insecticides of the Anopheles sp. mosquitoes that transmit the disease, socioeconomic problems that have led to a decreased capacity to optimally utilize existing tools to combat the disease, and movement of nonimmune populations into areas where malaria is transmitted. Accordingly, there are now renewed efforts to control this disease. A major focus of research efforts is to develop vaccines against malaria, including vaccines designed to produce protective cytotoxic T lymphocytes (CTL; HOFFMAN et al. 1991). To understand how such vaccines might work, it is important to understand the life cycle of the parasite.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1994
- Accession Number
- ADA283954
Entities
People
- Aditya Malik
- Martha Sedegah
- Stephen L. Hoffman
Organizations
- Naval Medical Research Center